مقایسه سطح سرمی بیومارکر NGAL قبل و بعد پیوند با شاخص‌های عملکرد گرافت

Authors

Abstract:

Background & Aims: Diagnosis of poor graft function by modern biomarkers is a step to early detection of injuries to the kidneys. Therefore, in this study, serum NGAL was evaluated in renal transplant recipients and compared with creatinine and glomerular filtration rate (GFR) using CKD-Epi equation. Materials & Methods: This case-control study was performed at Imam Khomeini Teaching Hospital, Urmia. Thirty-nine kidney transplant recipients from the living- and cadaver donors were investigated between February 2016 and September 2017. Serum NGAL predictive value during early postoperative period was investigated studied population was divided into good early graft function (GEGF) and poor early graft function (PEGF) as according to established protocol. Blood specimens were collected before transplantation and also 2, 16, 24, 36, and 48 hours after transplantation. NGAL was measured by ELISA method. The results were analyzed by SPSS software version 16. Results: Of 39 transplant recipients, 13 were classified as PEGF No difference was seen in serum NGAL between kidney recipients with GEGF or PEGF. Serum creatinine and GFR peri-transplantation and 2 hours after surgery were not different However, significant differences were observed 16, 24, 36, 48 and 72 hours post-surgery transplantation (p <0.05). The ROC analysis showed that the AUCs of creatinine varied from 0/76 to 0/87 and that for GFR varied from 0/72 to 0/86. Also, there was a positive correlation between serum NGAL measured in pre-graft and 2, 16, 24, 36, and 48 hours after transplantation with creatinine. No difference was noted in GFR monitored at3, 6, 9, and 12 months after transplantation. Conclusion: Our results indicated that serum NGAL was not significantly different among patients with GEFG and PEGF. Serum creatinin and GFR (CKD-EPI) were better than NGAL in diagnosing patients with PEGF, t High distribution living donors in this study was the main cause of the difference in the results of this study with other There was no positive correlation between the serum NGAL measured in the early hours of transplantation and one-year after transplantation.  

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

بررسی مقایسه ای سطح سرمی آدیپونکتین قبل و بعد از پیوند کلیه

  Background: Serum adiponectin has been proposed to have role in coronary disease and cardiovascular events in general population. Concentration of this protein increases in renal insufficiency but the role of kidney in adiponectin elimination is undetermined. The aim of this study WAS to compare the concentration of serum adiponectin before and after kidney transplantation and its association...

full text

مقایسه تأثیر وضعیت طاق باز و دمر بر وضعیت تنفسی نوزادان نارس مبتلا به سندرم دیسترس تنفسی حاد تحت درمان با پروتکل Insure

کچ ی هد پ ی ش مز ی هن ه و فد : ساسا د مردنس رد نامرد ي سفنت سرتس ي ظنت نادازون داح ي سکا لدابت م ي و نژ د ي سکا ي د هدوب نبرک تسا طسوت هک کبس اـه ي ناـمرد ي فلتخم ي هلمجزا لکتورپ INSURE ماجنا م ي دوش ا اذل . ي هعلاطم ن فدهاب اقم ي هس عضو ي ت اه ي ندب ي عضو رب رمد و زاب قاط ي سفنت ت ي هـب لاتـبم سراـن نادازون ردنس د م ي سفنت سرتس ي لکتورپ اب نامرد تحت داح INSURE ماجنا درگ ...

full text

بررسی مقایسه ای سطح سرمی آدیپونکتین قبل و بعد از پیوند کلیه

زمینه و هدف: آدیپونکتین سرمی به عنوان یک نشانگر احتمالی بیماری عروق کرونر و حوادث قلبی عروقی در جمعیت عمومی مطرح است. سطح این پروتئین در نارسایی کلیه به طور قابل توجهی افزایش می یابد اما نقش کلیه ها در حذف آدیپونکتین ناشناخته است.هدف این مطالعه مقایسه سطح سرمی آدیپونکتین قبل و بعد از پیوند کلیه و ارتباط آن با وضعیت عملکرد کلیه بعد از پیوند کلیه می باشد.   روش کار: در این مطالعه مقطعی تعداد 40 ن...

full text

مقایسه سطح هورمونهای جنسی و اسپرموگرام قبل و بعد از پیوند موفق کلیه

هدف اصلی این مطالعه بررسی و مقایسه هورمونهای جنسی و اسپرموگرام در بیماران مبتلا به نارسایی مزمن کلیه تحت درمان همودیالیز و به دنبال پیوند موفق کلیه می‌باشد. این مطالعه به روش مورد شاهدی طی سالهای 1377 و 1378 در بیمارستان سینا انجام شد. در 30 مرد تحت درمان همودیالیز با متوسط سن 38 سال (24 تا 52 سال) که حداقل 6 ماه دیالیز شده بودند، میزان پلاسمایی هورمونهای جنسی (FSH، LH، تستوسترون و پرولاکتین) و...

full text

مقایسه سطح سرمی منیزیم توتال در نوزادان مبتلا به زردی قبل و بعد از فتوتراپی

Background: Deposition of bilirubin in neurons causes permanent neuronal injury. Bilirubin exhibits an affinity for the phospholipids of plasma membrane like N-methyl-D-aspartate (NMDA) receptors. Magnesium is an NMDA antagonist and it acts against the neurotoxic effects of bilirubin. We compared pre- and post-phototherapy serum magnesium level of neonates with hyperbilirubinemia to find the be...

full text

ارزش تشخیصی سیستاتین ‌C‌ سرمی در گیرندگان پیوند کلیه با عملکرد اولیه ی ضعیف گرافت

Background & Aims: Despite improvements in surgical techniques and immunosuppression regimen, poor early graft function (PEGF) is a common problem among kidney recipient. PEGF has an effect on the short and long-term graft outcome. Its timely diagnosis, therefore, is of the main priorities. To date, an array of biochemical methods including classic routine- as well as innovative biomarkers has ...

full text

My Resources

Save resource for easier access later

Save to my library Already added to my library

{@ msg_add @}


Journal title

volume 29  issue 12

pages  848- 856

publication date 2019-03

By following a journal you will be notified via email when a new issue of this journal is published.

Keywords

No Keywords

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023